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CD8a Antibody

CAT: 0800-V2043IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2043IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD8 is a cell surface receptor expressed either as a heterodimer with the beta chain or as a homodimer. A majority of thymocytes and a subpopulation of mature Tcells and NK cells express CD8a. It binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in Tcell development and activation of mature Tcells. For mature Tcells, CD8 and 4 are mutually exclusive, so antibody to CD8 is generally used in conjunction with antibody to CD4. CD8a antibody is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral Tcell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+/CD8-, and in T-lymphoblastic lymphoma/leukemia, they are often co-expressed. It is also found in littoral cell angioma of the spleen.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P01732
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant protein was used as the immunogen for this CD8a antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
C8/468
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the CD8a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD8a antibody is available for research use only.
Storage Conditions
Store the CD8a antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface
Image Legend
IHC testing of FFPE human tonsil (20X) stained with CD8a antibody (C8/468) . Note cell surface staining.

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