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CDKN2D Antibody / p19-INK4d

CAT: 0800-RQ6844Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6844Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P55273
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein (amino acids E31-H132) was used as the immunogen for the CDKN2D antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the CDKN2D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CDKN2D antibody is available for research use only.
Storage Conditions
After reconstitution, the CDKN2D antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CDKN2D antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human U-87 MG cells with CDKN2D antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= CDKN2D antibody.

UniProtKB · P55273

Cyclin-dependent kinase 4 inhibitor D

CDN2D_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55273
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDKN2D
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q13102, Q6FGE9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Domain

ANK repeatRepeat

Biological process

Cell cycle

Cellular component

CytoplasmNucleus

Disease

Tumor suppressor
Product Datasheet
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