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5HT1B Antibody / HTR1B

CAT: 0800-RQ6562Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6562Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine) . Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P28222
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An E. coli-derived human protein (amino acids A35-S390) was used as the immunogen for the 5HT1B antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the 5HT1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This 5HT1B antibody is available for research use only.
Storage Conditions
After reconstitution, the 5HT1B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the 5HT1B antibody should be determined by the researcher.
Location
Cytoplasm, cell membrane
Image Legend
IHC staining of FFPE human rectal cancer tissue with 5HT1B antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · P28222

5-hydroxytryptamine receptor 1B

5HT1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28222
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HTR1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
5-HT-1B, 5-HT1B
EC number
—
Processing
—
Secondary accessions
Q4VAY7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Behavior

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix
Product Datasheet
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