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COPS5 Antibody / JAB1

CAT: 0800-RQ6537Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6537Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
Q92905
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
An E. coli-derived human protein (amino acids M8-S334) was used as the immunogen for the COPS5 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
4G9
Applications
WB, IHC-P, IF, FACS
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the COPS5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This COPS5 antibody is available for research use only.
Storage Conditions
After reconstitution, the COPS5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the COPS5 antibody should be determined by the researcher.
Location
Nuclear and cytoplasmic
Image Legend
IHC staining of FFPE human liver cancer tissue with COPS5 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q92905

COP9 signalosome complex subunit 5

CSN5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92905
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
COPS5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SGN5, Signalosome subunit 5
EC number
3.4.-.-
Processing
—
Secondary accessions
O15386, Q6AW95, Q86WQ4, Q9BQ17
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Cellular component

CytoplasmCytoplasmic vesicleNucleusSignalosomeSynapse

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Metal-bindingZinc
Product Datasheet
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