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CLCN5 Antibody / CIC-5

CAT: 0800-RQ6462Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6462Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CLCN5 gene encodes the chloride channel Cl-/H+ exchanger ClC-5. This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P51795
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An E. coli-derived human protein (amino acids R100-S756) was used as the immunogen for the CLCN5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the CLCN5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CLCN5 antibody is available for research use only.
Storage Conditions
After reconstitution, the CLCN5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CLCN5 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat brain, 2) rat liver, 3) rat heart, 4) rat kidney, 5) mouse brain, 6) mouse liver, 7) mouse heart and 8) mouse kidney tissue lysate with CLCN5 antibody. Expected molecular weight: 80-83 kDa (isoform 2) and 90-100 kDa (isoform 1) .

UniProtKB · P51795

H(+)/Cl(-) exchange transporter 5

CLCN5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51795
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLCN5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A1L475, B3KPN6, Q5JQD5, Q7RTN8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AntiportIon transportTransport

Ligand

ATP-bindingChlorideNucleotide-binding

Domain

CBS domainRepeatTransmembraneTransmembrane helix

Cellular component

Cell membraneEndosomeGolgi apparatusMembrane

Disease

Disease variant

PTM

Ubl conjugation

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