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Il4 receptor Antibody

CAT: 0800-RQ6186Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6186Size:100 µg
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Description
IL4R (INTERLEUKIN 4 RECEPTOR) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The IL4R gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E (IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain, a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor.The IL4R gene contains 12 exons and IL4R is a complex of at least 2 components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction. See also IL13RA1 and IL13RA2.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 2-5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q63257
Host
Rabbit
Reactivity
Rat, Mouse
Immunogen
A rat recombinant partial protein (amino acids I26-E719) was used as the immunogen for the Il4 receptor antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.0125% sodium azide
Reconstitution
After reconstitution, the Il4 receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Il4 receptor antibody is available for research use only.
Storage Conditions
After reconstitution, the Il4 receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Il4 receptor antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of mouse spleen cells with Il4 receptor antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= IL4 Receptor antibody.

UniProtKB · Q63257

Interleukin-4 receptor subunit alpha

IL4RA_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q63257
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Il4r
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA
EC number
—
Processing
Precursor
Secondary accessions
Q9R1W8, Q9WTM8
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Technical term

Reference proteome

Domain

SignalTransmembraneTransmembrane helix

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