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GPBAR1 Antibody / TGR5

CAT: 0800-RQ6095Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6095Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or TGR5 as is a protein that in humans is encoded by the GPBAR1 gene. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
Q8TDU6
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Amino acids DQRYTAPWRAAAQR from the human protein were used as the immunogen for the GPBAR1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the GPBAR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This GPBAR1 antibody is available for research use only.
Storage Conditions
After reconstitution, the GPBAR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the GPBAR1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat liver, 2) mouse liver and 3) mouse kidney lysate with GPBAR1 antibody. Predicted molecular weight: 35-50 kDa depending on glycosylation level.

UniProtKB · Q8TDU6

G protein-coupled bile acid receptor 1

GPBAR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TDU6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GPBAR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3KV35
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix
Product Datasheet
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