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AKR1D1 Antibody

CAT: 0800-RQ5955Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5955Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human delta (4) -3-oxosteroid 5-beta-reductase (steroid 5-beta-reductase) catalyzes 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta (4) -3-one structure. This gene is mapped to 7q33. The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta (4) -3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Immunofluorescence: 2-4 µg/mL
UniProt
P51857
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids KGACATSVKVAIDTGYRHIDGAYIYQNEHE from the human protein were used as the immunogen for the AKR1D1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS, IF
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the AKR1D1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This AKR1D1 antibody is available for research use only.
Storage Conditions
After reconstitution, the AKR1D1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the AKR1D1 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of FFPE human U-2 OS cells with AKR1D1 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P51857

Aldo-keto reductase family 1 member D1

AK1D1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51857
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AKR1D1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.3.1.3
Processing
—
Secondary accessions
A1L4P6, A8K060, B4DPN3, B4DPN8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Bile acid catabolismLipid degradationLipid metabolismSteroid metabolism

Cellular component

Cytoplasm

Disease

Disease variantIntrahepatic cholestasis

Ligand

NADP

Molecular function

Oxidoreductase

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