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PDE6 beta Antibody / PDE6B

CAT: 0800-RQ5910Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5910Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry: 1-2 µg/mL, Immunofluorescence: 2-4 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P35913
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human protein (amino acids K25-Q237) was used as the immunogen for the PDE6 beta antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the PDE6 beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PDE6 beta antibody is available for research use only.
Storage Conditions
After reconstitution, the PDE6 beta antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PDE6 beta antibody should be determined by the researcher.
Image Legend
Immunofluorescent staining of FFPE human A431 cells with PDE6 beta antibody (red) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P35913

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

PDE6B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35913
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDE6B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GMP-PDE beta
EC number
3.1.4.35
Processing
Precursor
Secondary accessions
B7Z9T9, E7ETT3, Q53XN5, Q9BWH5, Q9UD49
Protein keywords

PTM

AcetylationLipoproteinPrenylation

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionMembrane

Ligand

cGMPMagnesiumManganeseMetal-bindingZinc

Disease

Congenital stationary night blindnessDisease variantRetinitis pigmentosa

Molecular function

Hydrolase

Technical term

Proteomics identificationReference proteome

Domain

Repeat

Biological process

Sensory transductionVision

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