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MDM2 Antibody

CAT: 0800-RQ5828Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5828Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al. (1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q00987
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids QYIMTKRLYDEKQQHIVY from the human protein were used as the immunogen for the MDM2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the MDM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MDM2 antibody is available for research use only.
Storage Conditions
After reconstitution, the MDM2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MDM2 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human U-87 MG, 2) rat PC-12, 3) rat RH35, 4) mouse HEPA1-6, 5) mouse NIH 3T3 and 6) mouse ANA-1 lysate with MDM2 antibody. Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.

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