DCC Antibody / Deleted in Colorectal Carcinoma

DCC Antibody / Deleted in Colorectal Carcinoma

• Description: Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. It is mapped to 18q21.2. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
• CAS Number: 9007-83-4
• UniProt: P43146
• Host: Rabbit
• Immunogen: A human recombinant protein (amino acids Q851-F1447) was used as the immunogen for the DCC antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, IHC-P, Direct ELISA
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the DCC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This DCC antibody is available for research use only.