DBC1 Antibody / Deleted in breast cancer 1 / CCAR2

• Description:

  DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein and Cell cycle and apoptosis regulator protein 2 (CCAR2), is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF-Alpha, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF-Alpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER-Alpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.

• UniProt:

  Q8N163

• Host:

  Mouse

• Immunogen:

  Recombinant full-length human CCAR2 / KIAA1967 protein was used as the immunogen for the DBC1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2a

• Applications:

  FACS, IHC-P

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Aliquot the DBC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This DBC1 antibody is available for research use only.

• CAS Number:

  9007-83-4