CD46 Antibody

• Description:

  The protein encoded by the CD46 gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. [RefSeq]

• Specifications:

  Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200

• UniProt:

  P15529

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide specific to human CD46 was used as the immunogen for the CD46 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG

• Clone:

  AEI-3

• Type:

  Recombinant

• Applications:

  IHC-P, WB

• Purity:

  Affinity purified

• Format:

  Purified

• Buffer:

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

• Reconstitution:

  Store the CD46 antibody at -20oC.

• Limitations:

  This CD46 antibody is available for research use only.

• Storage Conditions:

  Store the CD46 antibody at -20°C.

• Formulation:

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

• Applications Notes:

  Optimal dilution of the CD46 antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Location:

  Plasma membrane

• Image Legend:

  Western blot testing of human K562 cell lysate with CD46 antibody. Observed molecular weight: 41~70 kDa depending on glycosylation level.