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CD46 Antibody

CAT: 0800-RQ5487Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5487Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by the CD46 gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P15529
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human CD46 was used as the immunogen for the CD46 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AEI-3
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CD46 antibody at -20oC.
Limitations
This CD46 antibody is available for research use only.
Storage Conditions
Store the CD46 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CD46 antibody should be determined by the researcher.
Location
Plasma membrane
Image Legend
Western blot testing of human K562 cell lysate with CD46 antibody. Observed molecular weight: 41~70 kDa depending on glycosylation level.
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