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Mcad Antibody / ACADM

CAT: 0800-RQ5361Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5361Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ACADM gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P11310
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Mcad / ACADM was used as the immunogen for the Mcad antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
COE-1
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Mcad antibody at -20oC.
Limitations
This Mcad antibody is available for research use only.
Storage Conditions
Store the Mcad antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Mcad antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa and 2) K562 cell lysate with Mcad antibody. Predicted molecular weight ~46 kDa.

UniProtKB · P11310

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

ACADM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11310
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACADM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MCAD
EC number
1.3.8.7
Processing
Precursor
Secondary accessions
Q5T4U4, Q9NYF1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Ligand

FADFlavoprotein

Biological process

Fatty acid metabolismLipid metabolism

Cellular component

Mitochondrion

Molecular function

Oxidoreductase

Domain

Transit peptide

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