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Granzyme B Antibody

CAT: 0800-RQ5315Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5315Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P10144
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Granzyme B / GZMB was used as the immunogen for the Granzyme B antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AAHC-7
Type
Recombinant
Applications
IHC-P
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Granzyme B antibody at -20oC.
Limitations
This Granzyme B antibody is available for research use only.
Storage Conditions
Store the Granzyme B antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Granzyme B antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human T-cell lymphoma tissue with Granzyme B antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

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