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HMBS Antibody / Hydroxymethylbilane synthase

CAT: 0800-RQ5215Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5215Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The HMBS gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P08397
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human HMBS was used as the immunogen for the HMBS antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
FEG-8
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the HMBS antibody at -20oC.
Limitations
This HMBS antibody is available for research use only.
Storage Conditions
Store the HMBS antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the HMBS antibody should be determined by the researcher.
Image Legend
Western blot testing of human HepG2 cell lysate with HMBS antibody. Predicted molecular weight ~39 kDa.

UniProtKB · P08397

Porphobilinogen deaminase

HEM3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08397
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HMBS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PBG-D
EC number
2.5.1.61
Processing
—
Secondary accessions
A8K2L0, G3V1P4, G5EA58, P08396, Q16012
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Disease

Disease variant

Biological process

Heme biosynthesisPorphyrin biosynthesis

Molecular function

Transferase
Product Datasheet
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