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Thymidylate Synthase Antibody

CAT: 0800-V3162IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V3162IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P04818
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this Thymidylate Synthase antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
TS106
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Thymidylate Synthase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Thymidylate Synthase antibody is available for research use only.
Storage Conditions
Store the Thymidylate Synthase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear & Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106) .

UniProtKB · P04818

Thymidylate synthase

TYSY_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04818
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TYMS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TS, TSase
EC number
2.1.1.45
Processing
—
Secondary accessions
Q8WYK3, Q8WYK4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion inner membraneNucleus

Disease

Disease variantDyskeratosis congenita

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

MethyltransferaseTransferase

Biological process

Nucleotide biosynthesis

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