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CD141 Antibody / Thrombomodulin

CAT: 0800-RQ5173Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5173Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by the intronless THBD gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P07204
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Thrombomodulin / CD141 was used as the immunogen for the CD141 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
COO-20
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CD141 antibody at -20oC.
Limitations
This CD141 antibody is available for research use only.
Storage Conditions
Store the CD141 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CD141 antibody should be determined by the researcher.
Location
Cell membrane, cytoplasmic
Image Legend
Western blot testing of human placenta lysate with CD141 antibody. Expected molecular weight: 60-100 kDa depending on glycosylation.

UniProtKB · P07204

Thrombomodulin

TRBM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07204
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
THBD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TM
EC number
—
Processing
Precursor
Secondary accessions
Q8IV29, Q9UC32
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Blood coagulationHemostasis

Disease

Disease variantHemolytic uremic syndromeThrombophilia

PTM

Disulfide bondGlycoproteinHydroxylationProteoglycan

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

Molecular function

Receptor
Product Datasheet
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