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Phospho-EIF2S1 Antibody (pS51)

CAT: 0800-RQ5120Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5120Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EIF2S1 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P05198
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human EIF2S1 (surrounding phosphorylated S51) was used as the immunogen for the phospho-EIF2S1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
IO-5
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the phospho-EIF2S1 antibody (pS51) at -20oC.
Limitations
This phospho-EIF2S1 antibody (pS51) is available for research use only.
Storage Conditions
Store the phospho-EIF2S1 antibody (pS51) at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the phospho-EIF2S1 antibody (pS51) should be determined by the researcher.
Image Legend
Western blot testing of lysate from human HeLa cells 1) treated with Calyculin A and 2) untreated, with phospho-EIF2S1 antibody (pS51) . Predicted molecular weight ~36 kDa.

UniProtKB · P05198

Eukaryotic translation initiation factor 2 subunit 1

IF2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05198
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EIF2S1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmMitochondrion

Molecular function

Initiation factorRNA-binding

Biological process

Protein biosynthesisTranslation regulation

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