Thymidylate Synthase Recombinant Antibody

Thymidylate Synthase Recombinant Antibody

• Description: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]
• CAS Number: 9000-83-3
• UniProt: P04818
• Host: Rabbit
• Immunogen: A synthetic peptide specific to human Thymidylate Synthase / TYMS was used as the immunogen for the Thymidylate Synthase antibody.
• Clonality: Monoclonal
• Isotype: IgG
• Type: Recombinant
• Applications: WB
• Format: Purified
• Buffer: Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
• Reconstitution: Store the Thymidylate Synthase antibody at -20oC.
• Limitations: This Thymidylate Synthase antibody is available for research use only.