Thymidylate Synthase Recombinant Antibody

Thymidylate Synthase Recombinant Antibody

• Description: It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
• CAS Number: 9000-83-3
• UniProt: P04818
• Host: Rabbit
• Immunogen: A recombinant human thymidylate synthase protein fragment (within amino acids 1-200) was used as the immunogen for the recombinant Thymidylate Synthase antibody.
• Clonality: Monoclonal
• Isotype: IgG κ
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the recombinant Thymidylate Synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This recombinant Thymidylate Synthase antibody is available for research use only.