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TEK Antibody / TIE2

CAT: 0800-RQ4918Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4918Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIE2, also known as TEK tyrosine kinase, is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF) -like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q02763
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids EALMNQHQDPLEVTQDVTREWAKKVVWK from the human protein were used as the immunogen for the TEK antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the TEK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TEK antibody is available for research use only.
Storage Conditions
After reconstitution, the TEK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TEK antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) placenta, 2) Caco-2, 3) human HeLa, 4) rat liver and 5) mouse liver lysate with TEK antibody at 0.5ug/ml. Predicted molecular weight: ~126 kDa but may be observable at 130-165 kDa.

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