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Caveolin-3 Antibody / CAV3

CAT: 0800-RQ4913Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4913Size:100 µg
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Description
Caveolin-3 is a protein that in humans is encoded by the CAV3 gene. This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD) . Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P56539
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids M1-D55 from the human protein were used as the immunogen for the Caveolin-3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Caveolin-3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Caveolin-3 antibody is available for research use only.
Storage Conditions
After reconstitution, the Caveolin-3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Caveolin-3 antibody should be determined by the researcher.
Location
Cytoplasmic, plasma membrane
Image Legend
Western blot testing of 1) human placenta, 2) U-87 MG, 3) human HeLa, 4) rat stomach, 5) rat testis, 6) mouse stomach and 7) mouse testis lysate with Caveolin-3 antibody at 0.5ug/ml. Predicted molecular weight: ~17 kDa but routinely observed at 20~25 kDa.

UniProtKB · P56539

Caveolin-3

CAV3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56539
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAV3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K777, Q3T1A4
Protein keywords

Disease

CardiomyopathyDisease variantLimb-girdle muscular dystrophyLong QT syndrome

Cellular component

Cell membraneGolgi apparatusMembrane

PTM

Isopeptide bondUbl conjugation

Technical term

Proteomics identificationReference proteome

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