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Histone H2B Antibody

CAT: 0800-RQ4765Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ4765Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1:5000-1:20000
UniProt
O60814
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Histone H2B / HIST1H2BK was used as the immunogen for the Histone H2B antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
HAD-8
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Histone H2B antibody at -20oC.
Limitations
This Histone H2B antibody is available for research use only.
Storage Conditions
Store the Histone H2B antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Histone H2B antibody should be determined by the researcher.
Image Legend
Western blot testing of human A431 cell lysate with Histone H2B antibody. Predicted molecular weight ~14 kDa.

UniProtKB · O60814

Histone H2B type 1-K

H2B1K_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60814
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
H2BC12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
H2B K
EC number
—
Processing
—
Secondary accessions
A8K7P7, Q2VPI7
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

PTM

AcetylationADP-ribosylationGlycoproteinHydroxylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

AntibioticAntimicrobialDNA-binding

Cellular component

ChromosomeNucleosome coreNucleus

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