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SHIP2 Antibody / INPPL1

CAT: 0800-RQ4578Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4578Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene. The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, Immunofluorescence/Immunocytochemistry (FFPE) : 2-4 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL (human recombinant protein)
UniProt
O15357
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids R1172-K1258 from the human protein were used as the immunogen for the SHIP2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF/ICC, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the SHIP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SHIP2 antibody is available for research use only.
Storage Conditions
After reconstitution, the SHIP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SHIP2 antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of human 1) placenta, 2) HeLa, 3) U-2 OS, 4) PC-3, 5) Caco-2, 6) A549 and 7) K562 lysate with SHIP2 antibody at 0.5ug/ml. Predicted molecular weight ~139 kDa (isoform 1), ~113 kDa (isoform 2) .

UniProtKB · O15357

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

SHIP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15357
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INPPL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.86
Processing
—
Secondary accessions
B2RTX5, Q13577, Q13578
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingHydrolase

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionImmunityLipid metabolism

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembraneNucleus

Disease

Diabetes mellitusDisease variant

Ligand

MagnesiumMetal-binding

PTM

Phosphoprotein

Domain

SH2 domainSH3-binding
Product Datasheet
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