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Cortactin Antibody

CAT: 0800-RQ4531Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4531Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cortactin, mapped to 11q13.3, is a multidomain protein. This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, IF/ICC (FFPE) : 1-2 µg/mL, FACS: 1-3ug/10^6 cells
UniProt
Q14247
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 1-105 from the human protein were used as the immunogen for this Cortactin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF/ICC, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Cortactin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Cortactin antibody is available for research use only.
Storage Conditions
After reconstitution, the Cortactin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Cortactin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasm, plasma membrane
Image Legend
Western blot testing of human 1) A431, 2) U-87 MG, 3) A549, 4) PC-3 and 5) HeLa lysate with Cortactin antibody at 0.5ug/ml. Predicted molecular weight ~61 kDa but routinely observed at ~80 kDa.

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