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HSP105 Antibody

CAT: 0800-RQ4470Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4470Size:100 µg
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Description
HSP105 (HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-3 µg/mL, Direct ELISA: 0.1-0.5 µg/mL (human recombinant protein)
UniProt
Q92598
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human Heat Shock Protein 105 recombinant protein (amino acids Y653-D858) was used as the immunogen for the HSP105 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the HSP105 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HSP105 antibody is available for research use only.
Storage Conditions
After reconstitution, the HSP105 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the HSP105 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human 1) HeLa, 2) placenta, 3) COLO-320, 4) SGC-7901, 5) HepG2, 6) K562, 7) Jurkat and 8) SK-OV-3 lysate with HSP105 antibody at 0.5ug/ml. Expected molecular weight: 105-110 kDa.

UniProtKB · Q92598

Heat shock protein 105 kDa

HS105_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92598
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSPH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DYH1, O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q9UPC4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cytoplasm

Biological process

Stress response

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