PROC Antibody / Protein C

CAT: 0800-RQ4412Size: 100 µgDry Ice: NoHazardous: No

1 / 1

CAT#:0800-RQ4412Size:100 µg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL

UniProt

P04070

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A human partial recombinant protein corresponding to amino acids D200-P461 was used as the immunogen for the PROC antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, ELISA

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Reconstitution

After reconstitution, the PROC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This PROC antibody is available for research use only.

Storage Conditions

After reconstitution, the PROC antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the PROC antibody should be determined by the researcher.

Image Legend

Western blot testing of 1) rat liver and 2) mouse liver with PROC antibody at 0.5ug/ml. Predicted molecular weight ~52 kDa.

UniProtKB · P04070

Vitamin K-dependent protein C

PROC_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04070
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PROC
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.4.21.69
Processing: Precursor
Secondary accessions: B4DPQ7, Q15189, Q15190, Q16001, Q53S74, Q9UC55

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Ligand

Calcium

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinHydroxylationPhosphoproteinZymogen

Disease

Disease variantThrombophilia

Domain

EGF-like domainRepeatSignal

Cellular component

Endoplasmic reticulumGolgi apparatusSecreted

Molecular function

HydrolaseProteaseSerine protease

Related Products

Catalog	Name
R30767	Protein C Antibody / PROC
RQ4438	C-Reactive Protein Antibody
R30203	C Reactive Protein Antibody
RQ4555	C Reactive Protein Antibody / CRP
F55062-0.2ML	SFTPC Antibody / Surfactant protein C
RQ5005	C Reactive Protein Antibody / CRP
FY12157	PKC Antibody / Protein kinase C
FY12733	CRP Antibody / C Reactive Protein
F55062-0.05ML	SFTPC Antibody / Surfactant protein C
F53636-0.1ML	CRP Antibody (C-Reactive Protein)

Alternative Products

Catalog	Name
abx100404-01	Protein C (PROC) Antibody
TRV-013648-01	Polyclonal Antibody to Protein C (PROC)
TRV-017733-01	Monoclonal Antibody to Protein C (PROC)
CAU27256-01	Protein C (PROC) Polyclonal Antibody
MBS9015754	Uncharacterized protein in proC 3'region Antibody
TA368246	Protein C (PROC) Rabbit Polyclonal Antibody
PA1682	Anti-Protein C/PROC Antibody Picoband®
TA423211	Protein C (PROC) Rabbit Monoclonal Antibody
GTR17986851	ProC Antibody