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Protein C Antibody / PROC

CAT: 0800-R30767Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30767Size:100 µg
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Description
Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of Protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated Protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for Protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated Protein C concentrates had been described in case reports and in one uncontrolled series.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P04070
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 446-461 (HGHIRDKEAPQKSWAP) were used as the immunogen for this Protein C antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Protein C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Protein C antibody is available for research use only.
Storage Conditions
After reconstitution, the Protein C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Protein C antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Protein C antibody and Lane 1: Jurkat; 2: CEM; 3: SMMC-7721; 4: HeLa cell lysate. Observed size: 35KD, predicted size: 52KD

UniProtKB · P04070

Vitamin K-dependent protein C

PROC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04070
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PROC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.69
Processing
Precursor
Secondary accessions
B4DPQ7, Q15189, Q15190, Q16001, Q53S74, Q9UC55
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Ligand

Calcium

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinHydroxylationPhosphoproteinZymogen

Disease

Disease variantThrombophilia

Domain

EGF-like domainRepeatSignal

Cellular component

Endoplasmic reticulumGolgi apparatusSecreted

Molecular function

HydrolaseProteaseSerine protease

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