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BNIP3 Antibody

CAT: 0800-RQ4194Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4194Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Bcl-2 nineteen kilodalton interacting protein 3 (BNIP3 or NIP3), is a hypoxia-inducible proapoptotic member of the Bcl-2 family that induces cell death by associating with the mitochondria. BNIP3, expressed in skeletal muscle and in the brain at low levels, is primarily localized to the nucleus of glial cells of the normal human brain, as well as in the malignant glioma cell line U251. BNIP3 expression in the cytoplasm increases and localizes with the mitochondria, contributing to induction of cell death. Cellular protein BNIP3 interacts with E1B-19K, BCL-2, BCL-xL, and EBV-BHRF1. BNIP3 contains Bcl-2 homology 3 (BH3) domain and COOH-terminal transmembrane (TM) domain. The BH3 domain of BNIP3 mediates Bcl-2/Bcl-X (L) heterodimerization and confers pro-apoptotic activity; whereas the TM domain is critical for homodimerization, pro-apoptotic function, and mitochondrial targeting.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL
UniProt
Q12983
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids KEFLFKHPKRTATLSMRNTSVMKK were used as the immunogen for the BNIP3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the BNIP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This BNIP3 antibody is available for research use only.
Storage Conditions
After reconstitution, the BNIP3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the BNIP3 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa, 2) A375 and 3) A549 cell lysate with BNIP3 antibody at 0.5ug/ml. Expected molecular weight: 19-21 kDa.
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