COL18A1 Antibody

CAT: 0800-RQ4192Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-RQ4192Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Collagen alpha-1 (XVIII) chain is a protein that in humans is encoded by the COL18A1 gene. This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL
UniProt
P39060
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein corresponding to amino acids H1572-K1754 was used as the immunogen for the COL18A1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the COL18A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This COL18A1 antibody is available for research use only.
Storage Conditions
After reconstitution, the COL18A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the COL18A1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human COLO320 and 2) human placenta lysate with COL18A1 antibody at 0.5ug/ml. Predicted molecular weight: ~178 (NC1-728), ~154 kDa (Long, NC-493), ~136 kDa (Short, NC1-303), ~20 kDa (Endostatin) .

Related Products

CatalogName
RQ4957COL17A1 Antibody
F43882-0.08MLCOL1A1 Antibody
F43882-0.4MLCOL1A1 Antibody
RQ4497Collagen XVII Antibody / COL17A1
F54164-0.2MLCOL14A1 Antibody (Center Region)
F54164-0.05MLCOL14A1 Antibody (Center Region)
F54619-0.4MLCOL8A2 Antibody
R36314-100UGCOL7A1 Antibody
F54619-0.08MLCOL8A2 Antibody
F54339-0.08MLCOL5A1 Antibody

Alternative Products

CatalogName
MBS7130667-01COL18A1 Antibody

Popular Products