EPO Receptor Antibody

CAT: 0800-RQ4024Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-RQ4024Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

CAS Number

9007-83-4

Specifications

Western Blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL

UniProt

P19235

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A recombinant human partial protein corresponding to amino acids E48-E226 was used as the immunogen for the EPO Receptor antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, ELISA

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Reconstitution

After reconstitution, the EPO Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This EPO Receptor antibody is available for research use only.

Storage Conditions

After reconstitution, the EPO Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the EPO Receptor antibody should be determined by the researcher.

Image Legend

Western blot testing of rat lung tissue with EPO Receptor antibody at 0.5ug/ml. Predicted molecular weight ~55 kDa (memebrane bound form), ~29 kDa (soluble form) .

UniProtKB · P19235

Erythropoietin receptor

EPOR_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P19235
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EPOR
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: EPO-R
EC number: —
Processing: Precursor
Secondary accessions: B2RCG4, Q15443, Q2M205

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Disease

Congenital erythrocytosisDisease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

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