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IL17RA Antibody

CAT: 0800-R32894Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32894Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. The IL17R gene is mapped to 22q11.22-q11.23 by radiation hybrid analysis. Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, ELISA (recombinant human protein) : 0.1-0.5 µg/mL
UniProt
Q96F46
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein corresponding to amino acids K53-Q284 was used as the immunogen for the IL17RA antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the IL17RA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IL17RA antibody is available for research use only.
Storage Conditions
After reconstitution, the IL17RA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the IL17RA antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) Jurkat and 2) MOLT4 cell lysate with IL17RA antibody at 0.5ug/ml. Predicted molecular weight ~97 kDa but can be observed at higher molecular weights due to glycosylation.

UniProtKB · Q96F46

Interleukin-17 receptor A

I17RA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96F46
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL17RA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-17 receptor A, IL-17RA
EC number
—
Processing
Precursor
Secondary accessions
O43844, Q20WK1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityHost-virus interactionImmunityInflammatory responseInnate immunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix
Product Datasheet
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