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MC1R Antibody

CAT: 0800-R32755Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32755Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH) . The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q01726
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 290-317 (NAIIDPLIYAFHSQELRRTLKEVLTCSW) from the human protein were used as the immunogen for the MC1R antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the MC1R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MC1R antibody is available for research use only.
Storage Conditions
After reconstitution, the MC1R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MC1R antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat PC12, 2) mouse Hepa1-6, 3) human HeLa and 4) human A375 cell lysate with MC1R antibody at 0.5ug/ml. Predicted molecular weight ~35 kDa.

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