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Choline acetyltransferase Antibody

CAT: 0800-R32706Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32706Size:100 µg
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Description
Choline acetyltransferase (also called ChAT or CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter acetylcholine. In humans, the choline acetyltransferase enzyme is encoded by the CHAT gene. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL
UniProt
P28329
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Amino acids D446-R652 from the human protein were used as the immunogen for the Choline acetyltransferase antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the Choline acetyltransferase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Choline acetyltransferase antibody is available for research use only.
Storage Conditions
After reconstitution, the Choline acetyltransferase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Choline acetyltransferase antibody should be determined by the researcher.
Prediction Reactivity
Human
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of 1) rat testis and 2) mouse testis tissue with Choline acetyltransferase antibody at 0.5ug/ml. Predicted molecular weight ~83/74/70 kDa (isoforms M/S/R), observed here at ~84 kDa.

UniProtKB · P28329

Choline O-acetyltransferase

CLAT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28329
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHAT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CHOACTase, ChAT, Choline acetylase
EC number
2.3.1.6
Processing
—
Secondary accessions
A2BDF4, A2BDF5, Q16488, Q9BQ23, Q9BQ35, Q9BQE1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

AcyltransferaseTransferase

Coding sequence diversity

Alternative splicing

Disease

Congenital myasthenic syndromeDisease variant

Biological process

Neurotransmitter biosynthesis

PTM

Phosphoprotein

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