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Emerin Antibody

CAT: 0800-R32593Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32593Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene. And this gene is mapped to Xq28. Emerin is a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Emery-Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene. Emerin appears to be involved in mechanotransduction, as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli. In cardiac muscle, emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs, and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Immunofluorescence (FFPE) : 2-4 µg/mL, Immunofluorescence/Immunocytochemistry (FFPE) : 2-4 µg/mL, Flow cytometry: 1-3ug/10^6 cells
Gene ID
2010
UniProt
P50402
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 1-48 (MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL-human) were used as the immunogen for the Emerin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF/ICC, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Emerin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Emerin antibody is available for research use only.
Storage Conditions
After reconstitution, the Emerin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Emerin antibody should be determined by the researcher.
Location
Nuclear membrane, nuclear
Image Legend
Western blot testing of 1) rat skeletal muscle, 2) mouse heart and 3) human HeLa lysate with Emerin antibody at 0.5ug/ml. Predicted molecular weight 29 kDa but routinely observed at ~34 kDa.

UniProtKB · P50402

Emerin

EMD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P50402
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EMD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6FI02
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Actin-binding

Disease

CardiomyopathyDisease variantEmery-Dreifuss muscular dystrophy

Cellular component

MembraneMicrotubuleNucleus

Domain

TransmembraneTransmembrane helix

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