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ADAMTS13 Antibody

CAT: 0800-R32496Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32496Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADAMTS13 (A disintegrin and metalloproteinase with athrombospondin type 1 motif, member 13), also known as VWFCP, is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. It is secreted in blood and degrades large vWf multimers, decreasing their activity. This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. This gene is mapped to 9q34.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA: 0.5-1 µg/mL (human protein tested) ; request BSA-free format for coating
UniProt
Q76LX8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids A299-R488 from the human protein were used as the immunogen for the ADAMTS13 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA (protein)
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the ADAMTS13 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ADAMTS13 antibody is available for research use only.
Storage Conditions
After reconstitution, the ADAMTS13 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Differences in protocols and secondary/substrate sensitivity may require the ADAMTS13 antibody to be titrated for optimal performance.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) rat brain, 2) mouse liver and 3) human HepG2 lysate with ADAMTS13 antibody at 0.5ug/ml. Predicted/observed molecular weight ~154 kDa.

UniProtKB · Q76LX8

A disintegrin and metalloproteinase with thrombospondin motifs 13

ATS13_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q76LX8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADAMTS13
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ADAM-TS 13, ADAM-TS13, ADAMTS-13
EC number
3.4.24.87
Processing
Precursor
Secondary accessions
Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3, Q9UGQ1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Ligand

CalciumMetal-bindingZinc

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinZymogen

Disease

Disease variant

Molecular function

HydrolaseMetalloproteaseProtease

Domain

RepeatSignal

Cellular component

Secreted

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