PD-L2 Antibody / CD273

• Description:

  Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. It is mapped to chromosome 9p24.2. PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. Northern blot analysis detect wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. PDL2 negatively regulates T cells and plays an essential role in immune tolerance.

• Specifications:

  Western blot: 0.5-1 µg/mL

• UniProt:

  Q9BQ51

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Amino acids L20-T220 were used as the immunogen for the PD-L2 antibody.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  WB

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

• Reconstitution:

  Prior to reconstitution, store at 4oC. After reconstitution, the PD-L2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

• Limitations:

  This PD-L2 antibody is available for research use only.

• Storage Conditions:

  Prior to reconstitution, store at 4°C. After reconstitution, the PD-L2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

• Formulation:

  0.5 mg/mL if reconstituted with 0.2ml sterile DI water

• Applications Notes:

  Optimal dilution of the PD-L2 antibody should be determined by the researcher.

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot testing of human HeLa cell lysate with PD-L2 antibody at 0.5ug/ml. Expected molecular weight: 31-60 kDa depending on glycosylation level.