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PD-L2 Antibody / CD273

CAT: 0800-R32447Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32447Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. It is mapped to chromosome 9p24.2. PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. Northern blot analysis detect wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. PDL2 negatively regulates T cells and plays an essential role in immune tolerance.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9BQ51
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids L20-T220 were used as the immunogen for the PD-L2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Prior to reconstitution, store at 4oC. After reconstitution, the PD-L2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PD-L2 antibody is available for research use only.
Storage Conditions
Prior to reconstitution, store at 4°C. After reconstitution, the PD-L2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PD-L2 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with PD-L2 antibody at 0.5ug/ml. Expected molecular weight: 31-60 kDa depending on glycosylation level.

UniProtKB · Q9BQ51

Programmed cell death 1 ligand 2

PD1L2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BQ51
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD1LG2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2
EC number
—
Processing
Precursor
Secondary accessions
Q14CN8, Q5T7Z6, Q6JXL8, Q6JXL9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

Receptor
Product Datasheet
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