MEF2A Antibody / Myocyte-specific enhancer factor 2A

MEF2A Antibody / Myocyte-specific enhancer factor 2A

• Description: Myocyte-specific enhancer factor 2A is a transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. [UniProt]
• CAS Number: 9007-83-4
• UniProt: Q02078
• Host: Rabbit
• Immunogen: Amino acids DGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRMDAWVT from the human protein were used as the immunogen for the MEF2A antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, IHC-P, IF
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the MEF2A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This MEF2A antibody is available for research use only.