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TGM2 Antibody

CAT: 0800-R32370Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32370Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transglutaminase 2, also called TGC, TG2 and TGM2, is a 78-kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. Transglutaminases (TGs) are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of TGs are not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Transglutaminase 2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It is the autoantigen implicated in celiac disease.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, IHC (Frozen) : 0.5-1 µg/mL
UniProt
P21980
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids LERCDLELETNGRDHHTADLCREKLVVR (human) used as the immunogen for this TGM2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the TGM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TGM2 antibody is available for research use only.
Storage Conditions
After reconstitution, the TGM2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the TGM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, cell surface
Image Legend
Western blot testing of TGM2 antibody and Lane 1: rat liver, 2. rat ovary and 3: HeLa lysate. Predicted/observed molecular weight: ~ 78 kDa.

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