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HDAC11 Antibody

CAT: 0800-R32306Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32306Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This gene encodes a class IV histone deacetylase. And the encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. In addition, HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q96DB2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids NFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLN of human HDAC11 were used as the immunogen for the HDAC11 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the HDAC11 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HDAC11 antibody is available for research use only.
Storage Conditions
After reconstitution, the HDAC11 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the HDAC11 antibody should be determined by the researcher.
Location
Predominantly nuclear
Image Legend
Western blot testing of rat 1) skeletal muscle, 2) kidney, 3) heart, 4) NRK, and human 5) 293, 6) HeLa and 7) MCF7 lysate with HDAC11 antibody. Expected/observed molecular weight ~39 kDa.

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