TGFBR1 Antibody

CAT: 0800-R32084Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R32084Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS) . TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss (1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
P36897
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids HNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTT of human TGFBR1 were used as the immunogen for the TGFBR1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the TGFBR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TGFBR1 antibody is available for research use only.
Storage Conditions
After reconstitution, the TGFBR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TGFBR1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa and 2) SW579 cell lysate with TGFBR1 antibody. Expected molecular weight ~55 kDa.

Related Products

CatalogName
RQ6526TGF-beta receptor type-1 Antibody / TGFBR1
RZ1180Zebrafish Tgfb1 Antibody / Tgfb1a / Tgf beta
F41742-0.08MLTGFBR2 Antibody
R30965TGFBR2 Antibody
F45533-0.08MLTgfbr2 Antibody
F41742-0.4MLTGFBR2 Antibody
F45533-0.4MLTgfbr2 Antibody
F55055-0.4MLTGFB1 Antibody
F53036-0.08MLTGFB1 Antibody
F55055-0.08MLTGFB1 Antibody

Alternative Products

CatalogName
FNab08643TGFBR1 antibody

Popular Products