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GRK3 Antibody / ADRBK2

CAT: 0800-R32079Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32079Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Beta-adrenergic receptor kinase 2 (beta-ARK-2), also known as G-protein-coupled receptor kinase 3 (GRK3), is an enzyme that in humans is encoded by the ADRBK2 gene. The human ADRBK2 gene is located on 22q11. The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Immunofluorescence (FFPE) : 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P35626
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids ESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPR of human GRK3/ADRBK2 were used as the immunogen for the GRK3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the GRK3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This GRK3 antibody is available for research use only.
Storage Conditions
After reconstitution, the GRK3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the GRK3 antibody should be determined by the researcher.
Image Legend
Immunofluorescent staining of FFPE human U-2 OS cells with GRK3 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P35626

G protein-coupled receptor kinase 3

GRK3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35626
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GRK3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.16
Processing
—
Secondary accessions
Q9UGW9
Protein keywords

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell projectionSynapse

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Technical term

Proteomics identificationReference proteome

PTM

Ubl conjugation
Product Datasheet
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