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Peroxiredoxin 5 Antibody

CAT: 0800-R32051Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32051Size:100 µg
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Description
PRDX5 (Peroxiredoxin 5) also known as PMP20, PRDX6, PRXV, SBBI10, is a member of the peroxiredoxin family and may play an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes. The PRDX5 gene is mapped to11q13.1. PRDX5 displays mitochondrial presequence features and has 3 cysteines implicated in antioxidant activity and a C-terminal SQL peroxisomal targeting sequence. Northern blot analysis revealed ubiquitous expression of a 1.0-kb PRDX5 transcript in tissues and cell lines. Functional analysis showed that PRDX5 has antioxidant activity equivalent to that of CAT. While PRDX5 was localized to fibroblasts in normal tendon, it was localized to fibroblasts and endothelial cells in degenerative tendon. PRDX5 mRNA and protein levels increased at 12 hours, and the increase in PRDX5 expression correlated with reduced peroxide levels. PRDX5 plays a protective role against oxidative stress in human cartilage.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Immunocytochemistry: 0.1-0.5 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL, Immunofluorescence (FFPE) : 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P30044
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 66-198 of human Peroxiredoxin 5 were used as the immunogen for the Peroxiredoxin 5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Peroxiredoxin 5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Peroxiredoxin 5 antibody is available for research use only.
Storage Conditions
After reconstitution, the Peroxiredoxin 5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Peroxiredoxin 5 antibody should be determined by the researcher.
Location
Cytoplasmic (mitochondrial)
Image Legend
Immunofluorescent staining of FFPE human HeLa cells with Peroxiredoxin 5 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P30044

Peroxiredoxin-5, mitochondrial

PRDX5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30044
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRDX5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.11.1.24
Processing
Precursor
Secondary accessions
A6NC19, A6NG06, B7ZLJ4, B7ZVW3, Q14CK0, Q6IAF2, Q9UBU5, Q9UJU4, Q9UKX4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondLipoproteinPalmitatePhosphoprotein

Coding sequence diversity

Alternative initiationAlternative splicing

Molecular function

AntioxidantOxidoreductasePeroxidase

Cellular component

CytoplasmMitochondrionPeroxisome

Domain

Redox-active centerTransit peptide

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