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LCK Antibody

CAT: 0800-R31894Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31894Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lck (or lymphocyte-specific protein tyrosine kinase) is a protein found inside specialized cells of the immune system called lymphocytes. The human LCK gene is mapped to chromosome 1p35-p32. This gene is a member of the Src family of protein tyrosine kinases (PTKs) . The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL, Flow cytometry: 1-3ug/10^6 cells, Immunocytochemistry: 2-4 µg/mL
UniProt
P06239
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids ELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQ of human Lymphocyte-specific protein tyrosine kinase were used as the immunogen for the LCK antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the LCK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This LCK antibody is available for research use only.
Storage Conditions
After reconstitution, the LCK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the LCK antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) human Jurkat, 2) rat thymus, 3) rat spleen, 4) mouse thymus and 5) mouse spleen lysate with LCK antibody. Expected/observed molecular weight ~58 kDa.

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