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Vitronectin Antibody / VTN

CAT: 0800-R31877Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31877Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vitronectin, also known as VTN, is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Also vitronectin serves to regulate proteolysis initiated by plasminogen activation. In addition, vitronectin is a component of platelets and is, thus, involved in hemostasis.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P04004
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids RVNLRTRRVDTVDPPYPRSIAQYWLGC of human Vitronectin were used as the immunogen for the Vitronectin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Vitronectin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Vitronectin antibody is available for research use only.
Storage Conditions
After reconstitution, the Vitronectin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Vitronectin antibody should be determined by the researcher.
Location
Cytoplasmic, membrane
Image Legend
Western blot testing of 1) rat liver, 2) rat lung, 3) human HepG2, 4) HeLa and 5) mouse HEPA1-6 lysate with Vitronectin antibody. Expected molecular weight: 54-75 kDa depending on glycosylation level.

UniProtKB · P04004

Vitronectin

VTNC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04004
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VTN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VN
EC number
—
Processing
Precursor
Secondary accessions
B2R7G0, P01141, Q9BSH7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Cell adhesion

PTM

Disulfide bondGlycoproteinPhosphoproteinSulfation

Molecular function

Heparin-binding

Domain

RepeatSignal

Cellular component

Secreted
Product Datasheet
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