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MCL1 Antibody

CAT: 0800-R31553Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31553Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Myeloid cell leukemia 1 is a protein that in humans is encoded the MCL1 gene. It is a potent multidomain antiapoptotic protein of the BCL2 family that heterodimerizes with other BCL2 family members to protect against apoptotic cell death. MCL1 as an attractive candidate for regulation of hematopoietic stem cell homeostasis that is highly expressed in hematopoietic stem cells and regulated by growth factor signals. It is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors. During mitotic arrest, MCL1 protein levels decline markedly, through a posttranslational mechanism, potentiating cell death. Phosphorylation of the protein directs its interaction with the tumor suppressor protein FBW7, which is the substrate-binding component of a ubiquitin ligase complex.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human partial recombinant protein (AA 1-350) was used as the immunogen for this MCL1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the MCL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MCL1 antibody is available for research use only.
Storage Conditions
After reconstitution, the MCL1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MCL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MCL1 antibody and Lane 1: rat spleen; 2: human HEPG2; 3: (h) MCF-7; 4: (h) COLO320. Predicted molecular weight ~37kDa.

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