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RIP1 Antibody / RIPK1

CAT: 0800-R31540Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31540Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK1, also known as RIP or RIP1, is an enzyme that in humans is encoded by the RIPK1 gene. It is mapped to 6p25.2. RIPK1 is a key signaling molecule in the programmed necrosis pathway, which plays important roles in development, tissue damage response, and antiviral immunity. RIPK1 is known to have function in a variety of cellular pathways including the NF-kB pathway and programmed necrotic cell death (necroptosis) . The kinase domain, while important for necroptotic (programmed necrotic) functions, it appears dispensable for other lethal, as well as pro-survival roles. Also, proteolytic processing of RIPk1, through both caspase-dependent and -independent mechanisms, triggers lethality that is dependent on the generation of one or more specific C-terminal cleavage product (s) of RIPk1 upon stress.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q13546
Host
Rabbit
Reactivity
Human
Immunogen
Human partial recombinant protein (AA 316-671) was used as the immunogen for this RIP1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the RIP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RIP1 antibody is available for research use only.
Storage Conditions
After reconstitution, the RIP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the RIP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of RIP1 antibody and Lane 1: Jurkat; 2: 22RV1; 3: MCF-7; 4: HeLa; 5: A549. Expected/observed size ~76 kDa.

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