RIP Antibody / RIPK1

CAT: 0800-R31162Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R31162Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), also called RIP, is an enzyme that in humans is encoded by the RIPK1 gene. Members of the TRAF protein family have been implicated in the activation of NF-kappa-B by the TNF superfamily. By yeast 2-hybrid and coimmunoprecipitation studies using mammalian cell extracts, Hsu et al. (1996) showed that RIP interacts with TRADD, TRAF1, TRAF2, and TRAF3. Hartz (2012) mapped the RIPK1 gene to chromosome 6p25.2 based on an alignment of the RIP sequence with the genomic sequence. Stanger et al. (1995) found that overexpression of Rip in mammalian cells induced morphologic changes characteristic of apoptosis. They suggested that RIP may be an important element in the signal transduction machinery that mediates programmed cell death.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q13546
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human Receptor-interacting serine/threonine-protein kinase 1 (RRRRVSHDPFAQQRP) was used as the immunogen for this RIP antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the RIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RIP antibody is available for research use only.
Storage Conditions
After reconstitution, the RIP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the RIP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 1) K562, 2) HeLa, 3) Raji and 4) Jurkat cell lysate with RIP antbody. Expected molecular weight ~76 kDa.

Related Products

CatalogName
R31540RIP1 Antibody / RIPK1
F43338-0.08MLRIPK1 Antibody
F43338-0.4MLRIPK1 Antibody
FY13346Phospho-RIP3 (Ser232) Antibody / RIPK3
F50790-0.08MLRIPK4 Antibody
F43229-0.4MLRIPK2 Antibody
F50800-0.08MLRIPK2 Antibody
F43947-0.08MLRIPK3 Antibody
F50801-0.4MLRIPK3 Antibody
F50171-0.08MLRIPK3 Antibody

Alternative Products

CatalogName
MBS8604180-01RIPK1 Antibody

Popular Products