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MMP7 Antibody

CAT: 0800-R31469Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31469Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matrix metalloproteinase-7, previously called putative metalloproteinase I (PUMP1) or Matrilysin has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The MMP7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively) . Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, MMP7 mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. MMP7 is also a mediator of pulmonary fibrosis and a potential therapeutic target.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL (mouse protein tested) ; request BSA free format for coating
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Mouse partial recombinant protein (AA 95-264) was used as the immunogen for this MMP7 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA (protein)
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with trehalose
Reconstitution
After reconstitution, the MMP7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MMP7 antibody is available for research use only.
Storage Conditions
After reconstitution, the MMP7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MMP7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MMP7 antibody and rat brain lysate. Predicted molecular weight ~30kDa.

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